Publication
CHEK2 mutation and risk of prostate cancer: a systematic review and meta-analysis.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Prostate Neoplasmcivic_curation1.00
- geneCHEK2civic_curation1.00
- variantCHEK2 1100DELCcivic_curation1.00
- variantCHEK2 I157Tcivic_curation1.00
- variantCHEK2 IVS2+1G>Acivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26629066
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CHEK2 1100DELC2 | ||||||||
| (predisposing) | Malignant Prostate Neoplasm | Predisposing | B | Supports Predisposition | 3 | rejected | EID1849Meta-analysis linking CHEK2 1100delC to a higher risk in prostate cancer ((OR 3.29; 95% confidence interval: 1.85-5.85; P = 0.00) ). PMID 26629066 · Wang et al., 2015 · Open in CIViC | civic |
| 〃 | Malignant Prostate Neoplasm | Predisposing | B | Supports Predisposition | 3 | accepted | EID1850Meta-analysis linking CHEK2 1100delC to a higher risk of prostate cancer (OR 3.29; 95% confidence interval: 1.85-5.85; P = 0.00). PMID 26629066 · Wang et al., 2015 · Open in CIViC | civic |
| CHEK2 I157T1 | ||||||||
| (predisposing) | Malignant Prostate Neoplasm | Predisposing | B | Supports Predisposition | 3 | accepted | EID1852Meta-analysis of 4 retrospective studies linked CHEK2 I157T to a higher risk of prostate cancer (OR 1.80; 95% confidence interval: 1.51-2.14; P = 0.00). PMID 26629066 · Wang et al., 2015 · Open in CIViC | civic |
| CHEK2 IVS2+1G>A1 | ||||||||
| (predisposing) | Malignant Prostate Neoplasm | Predisposing | B | Does Not Support Predisposition | 2 | accepted | EID1854Meta-analysis of 2 studies of CHEK2 and prostate cancer showing that the IVS2+1G>A mutation is irrelevant as a predictor of prostate cancer. PMID 26629066 · Wang et al., 2015 · Open in CIViC | civic |