Publication
A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerOvarian Gynandroblastomacivic_curation1.00
- cancerOvarian Sertoli-Leydig Cell Tumorcivic_curation1.00
- geneDICER1civic_curation1.00
- variantDICER1 D1709Ncivic_curation1.00
- variantDICER1 E1705Kcivic_curation1.00
- variantDICER1 E1813Qcivic_curation1.00
Curated evidence
Evidence citing this paper (5)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26428316
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| DICER1 E1705K2 | ||||||||
| (diagnostic) | Ovarian GynandroblastomaALIAS | Diagnostic | C | Supports Positive | 2 | accepted | EID11480In an analysis of a range of different ovarian sex cord-stromal tumors, 2 of 5 gynandroblastomas were found to have the DICER1 E1705K hotspot mutation supporting a role for DICER1 in a subset of these… (full text at CIViC) PMID 26428316 · Conlon et al., 2015 · Open in CIViC | civic |
| 〃 | Ovarian Sertoli-Leydig Cell TumorALIAS | Diagnostic | B | Supports Positive | 4 | accepted | EID5533Sanger sequencing identified DICER1 hotspot mutations in 20 of 32 (63%) ovarian Sertoli–Leydig cell tumors. These mutations were unrelated to tumor differentiation and mostly (16/20, 80%) were E1705K.… (full text at CIViC) PMID 26428316 · Conlon et al., 2015 · Open in CIViC | civic |
| DICER1 D1709N1 | ||||||||
| (diagnostic) | Ovarian Sertoli-Leydig Cell TumorALIAS | Diagnostic | B | Does Not Support Positive | 4 | accepted | EID5534In this exploratory study of Sertoli-Leydig cell tumors, DICER1 mutations were found in over half of the samples sequenced, but were not found to have any role in tumorigenesis, contrary to what was p… (full text at CIViC) PMID 26428316 · Conlon et al., 2015 · Open in CIViC | civic |
| DICER1 E1813Q1 | ||||||||
| (diagnostic) | Ovarian Sertoli-Leydig Cell TumorALIAS | Diagnostic | B | Does Not Support Positive | 4 | accepted | EID5535In this exploratory study of Sertoli-Leydig cell tumors, DICER1 mutations were found in over half of the samples sequenced, but were not found to have any role in tumorigenesis, contrary to what was p… (full text at CIViC) PMID 26428316 · Conlon et al., 2015 · Open in CIViC | civic |
| DICER1 G1809R1 | ||||||||
| (diagnostic) | Ovarian Sertoli-Leydig Cell TumorALIAS | Diagnostic | C | Supports Positive | 2 | submitted | EID12324Sanger sequencing identified DICER1 hotspot mutations in 20 of 32 (63%) ovarian Sertoli–Leydig cell tumors. These mutations were unrelated to tumor differentiation and mostly (16/20, 80%) were E1705K.… (full text at CIViC) PMID 26428316 · Conlon et al., 2015 · Open in CIViC | civic |