Publication

Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion.

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Br J Haematol2015PMID 26404892stubpubmedPublished

Abstract

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Linked entities

Linked entities (3)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 3

cancerB Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Likecivic_curation1.00
geneJAK2civic_curation1.00
variantJAK2 Fusioncivic_curation1.00

Curated evidence

Evidence citing this paper (2)

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
JAK2 Fusion2
(diagnostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	2	accepted	EID7997 To identify potentially druggable kinase fusions, this study of 278 B-ALL patients (all BCR-ABL1 negative), 34 (12.2%) harbored an IKZF1 deletion as determined by MLPA. Sufficient RNA from 16/34 of th… (full text at CIViC) PMID 26404892 · Yano et al., 2015 · Open in CIViC	civic
〃	Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED	Diagnostic	E	Supports Positive	3	rejected	EID7995 In B-lymphoblastic leukemia/lymphoma (B-ALL), the presence of this fusion is associated with so-called BCR/ABL1 like (Ph-like) subtype of the disease. The OFD1-JAK2 fusion is rare; in this study invol… (full text at CIViC) PMID 26404892 · Yano et al., 2015 · Open in CIViC	civic