Publication
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- geneIDH1civic_curation1.00
- geneIDH2civic_curation1.00
- variantIDH1 Mutationcivic_curation1.00
- variantIDH2 Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26061751
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ATRX Mutation1 | ||||||||
| (diagnostic) | Anaplastic AstrocytomaALIAS | Diagnostic | B | Supports Positive | 5 | submitted | EID8950293 adult cases of low grade gliomas (LGGs) underwent a variety of analyses, including but not limited to exome sequencing (289 samples), copy number profiling (285), mRNA sequencing (277) and sequenc… (full text at CIViC) PMID 26061751 · 2015, N. Engl. J. Med. · Open in CIViC | civic |
| IDH1 Mutation1 | ||||||||
| (prognostic) | Brain GliomaUNRESOLVED | Prognostic | B | Supports Better Outcome | 3 | accepted | EID1639Genomewide analysis of 250 low-grade adult gliomas revealed that patients with a wildtype IDH1/2 had significantly shorter overall survival than those with a mutated IDH gene (HR 7.4; 95%CI: 4.0-13.8)… (full text at CIViC) PMID 26061751 · 2015, N. Engl. J. Med. · Open in CIViC | civic |
| IDH2 Mutation1 | ||||||||
| (prognostic) | Brain GliomaUNRESOLVED | Prognostic | B | Supports Better Outcome | 3 | accepted | EID1640Genomewide analysis of 250 low-grade adult gliomas revealed that patients with a wildtype IDH1/2 had significantly shorter overall survival than those with a mutated IDH gene (HR 7.4; 95%CI: 4.0-13.8)… (full text at CIViC) PMID 26061751 · 2015, N. Engl. J. Med. · Open in CIViC | civic |