Publication
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity.
Authors not recorded
Nature2015PMID 25970248stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMelanomacivic_curation1.00
- drugAnti-CTLA-4 Monoclonal Antibodycivic_curation1.00
- drugAnti-PD-L1 Monoclonal Antibodycivic_curation1.00
- geneCTNNB1civic_curation1.00
- variantCTNNB1 Activating Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25970248
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CTNNB1 Activating Mutation1 | ||||||||
| Anti-CTLA-4 Monoclonal Antibody + Anti-PD-L1 Monoclonal AntibodySubstitutes | Melanoma | Predictive | D | Supports Resistance | 4 | accepted | EID2988Activation of melanoma-cell-intrinsic WNT/β-catenin signalling pathway contributes to a lack of T-cell infiltration in melanoma. Molecular analysis of human metastatic melanoma samples revealed a corr… (full text at CIViC) PMID 25970248 · Spranger et al., 2015 · Open in CIViC | civic |