Publication
Personalized oncogenomics: clinical experience with malignant peritoneal mesothelioma using whole genome sequencing.
Authors not recorded
PLoS One2015PMID 25798586PMC4370594stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerPeritoneal Mesothelial Neoplasmcivic_curation1.00
- drugCarboplatincivic_curation1.00
- drugCisplatincivic_curation1.00
- geneNF2civic_curation1.00
- variantNF2 Y177fscivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25798586
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NF2 Y177fs1 | ||||||||
| Carboplatin + CisplatinSubstitutes | Peritoneal Mesothelial NeoplasmALIAS | Predictive | C | Supports Resistance | 3 | accepted | EID649A frameshift mutation in NF2 at position Y177 was found in a patient who responded poorly to therapy and died within 8 months of diagnosis. Initially treated with 3 cycles of systemic chemotherapy wit… (full text at CIViC) PMID 25798586 · Sheffield et al., 2015 · Open in CIViC | civic |