Publication
Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers.
Authors not recorded
Nat Med2015PMID 25686104PMC4352133stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- drugGSK126civic_curation1.00
- geneARID1Acivic_curation1.00
- variantARID1A Losscivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25686104
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ARID1A Loss1 | ||||||||
| GSK126 | Ovarian Clear Cell CarcinomaUNRESOLVED | Predictive | D | Supports Sensitivity Response | 4 | accepted | EID2983A screen was performed to identify small molecule inhibitors that inhibit growth of ARID1A inactivated cells using shRNA knockdown in ARID1A wild-type ovarian clear cell carcinoma (OCCC) cell line RMG… (full text at CIViC) PMID 25686104 · Bitler et al., 2015 · Open in CIViC | civic |