Publication
ERBB2 Mutations Characterize a Subgroup of Muscle-invasive Bladder Cancers with Excellent Response to Neoadjuvant Chemotherapy.
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- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerBladder Carcinomacivic_curation1.00
- drugPlatinum Compoundcivic_curation1.00
- geneERBB2civic_curation1.00
- variantERBB2 Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (13)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25636205
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ERBB2 D769H1 | ||||||||
| Chemotherapy | Bladder Carcinoma | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID11499Variant found in a patient that was diagnosed with muscle-invasive bladder cancer in pretreatment transurethral resection tumor samples (Fig. 1; Patients ID:CF3097). The patient was categorised as a “… (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |
| ERBB2 Mutation1 | ||||||||
| Platinum Compound | Bladder Carcinoma | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID1694In patients with muscle-invasive bladder chancer, a cohort of complete responders to platinum chemotherapy (n=38) and non-responders to platinum chemotherapy (n=33) were evaluated for 178 cancer-assoc… (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |
| ERBB2 R678L1 | ||||||||
| Chemotherapy | Bladder Carcinoma | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID11498Variant found in a patient that was diagnosed with muscle-invasive bladder cancer in pretreatment transurethral resection tumor samples (Fig. 1; Patients ID: CF3122). The patient was categorised as a … (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |
| ERBB2 S310F1 | ||||||||
| Chemotherapy | Bladder Carcinoma | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID11496Variant found in patient's that were diagnosed with muscle-invasive bladder cancer in pretreatment transurethral resection tumor samples (Fig. 1; Patients ID: 9013, CF0943, CF0945, CF1005, CF0955). Th… (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |
| ERBB2 S310F + ERBB2 T306M1 | ||||||||
| Chemotherapy | Bladder Carcinoma | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID11497Variants were found in a patient that was diagnosed with muscle-invasive bladder cancer in pretreatment transurethral resection tumor samples (Fig. 1; Patients ID: 9013). The patient was categorised a… (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |
| ERBB2 V777M1 | ||||||||
| Chemotherapy | Bladder Carcinoma | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID11500Variant found in a patient that was diagnosed with muscle-invasive bladder cancer in pretreatment transurethral resection tumor samples (Fig. 1; Patients ID:CF0940). The patient was categorised as a “… (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |
| ERBB2 V842I1 | ||||||||
| Chemotherapy | Bladder Carcinoma | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID11501Variant found in a patient that was diagnosed with muscle-invasive bladder cancer in pretreatment transurethral resection tumor samples (Fig. 1; Patients ID:CF0977). The patient was categorised as a “… (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |
| ERCC2 D257N1 | ||||||||
| Chemotherapy | Bladder Carcinoma | Predictive | C | Does Not Support Sensitivity Response | 2 | submitted | EID11506Variant found in a patient that was diagnosed with muscle-invasive bladder cancer in pretreatment transurethral resection tumor samples (Supplementary Table 4; Patients ID: CF0959). The patient was ca… (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |
| ERCC2 E86Q1 | ||||||||
| Chemotherapy | Bladder Carcinoma | Predictive | C | Does Not Support Sensitivity Response | 2 | submitted | EID11503Variant found in a patient that was diagnosed with muscle-invasive bladder cancer in pretreatment transurethral resection tumor samples (Supplementary Table 4; Patients ID: CF1000). The patient was ca… (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |
| ERCC2 N238S1 | ||||||||
| Chemotherapy | Bladder Carcinoma | Predictive | C | Does Not Support Sensitivity Response | 2 | submitted | EID11505Variant found in patients that were diagnosed with muscle-invasive bladder cancer in pretreatment transurethral resection tumor samples (Supplementary Table 4; Patients ID: CF0949, CF0982, CF3098). Th… (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |
| ERCC2 S44L1 | ||||||||
| Chemotherapy | Bladder Carcinoma | Predictive | C | Does Not Support Sensitivity Response | 2 | submitted | EID11502Variant found in a patient that was diagnosed with muscle-invasive bladder cancer in pretreatment transurethral resection tumor samples (Supplementary Table 4; Patients ID: CF0950). The patient was ca… (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |
| ERCC2 T484M1 | ||||||||
| Chemotherapy | Bladder Carcinoma | Predictive | C | Does Not Support Sensitivity Response | 2 | submitted | EID11507Variant found in a patient that was diagnosed with muscle-invasive bladder cancer in pretreatment transurethral resection tumor samples (Supplementary Table 4; Patients ID: CF0979). The patient was ca… (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |
| ERCC2 Y72C1 | ||||||||
| Chemotherapy | Bladder Carcinoma | Predictive | C | Does Not Support Sensitivity Response | 2 | submitted | EID11504Variant found in a patient that was diagnosed with muscle-invasive bladder cancer in pretreatment transurethral resection tumor samples (Supplementary Table 4; Patients ID: CF1005). The patient was ca… (full text at CIViC) PMID 25636205 · Groenendijk et al., 2016 · Open in CIViC | civic |