Publication
Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ.
Authors not recorded
Cancer Cell2015PMID 25544636PMC4293347stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerProstate Adenocarcinomacivic_curation1.00
- drugAlpelisibcivic_curation1.00
- drugEnzalutamidecivic_curation1.00
- drugPI3Kbeta Inhibitor AZD8186civic_curation1.00
- genePTENcivic_curation1.00
- variantPTEN Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25544636
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PTEN Mutation1 | ||||||||
| Alpelisib + Enzalutamide + PI3Kbeta Inhibitor AZD8186Combination | Prostate Adenocarcinoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1522Castrated mice bearing androgen-sensitive human prostate adenocarcinomas (LNCaP tumors) were treated with PI3K inhibitors (AZD8186, BYL719) and an androgen receptor inhibitor (MDV3100). Mice treated … (full text at CIViC) PMID 25544636 · Schwartz et al., 2015 · Open in CIViC | civic |