Publication
Mutational landscape of aggressive cutaneous squamous cell carcinoma.
Authors not recorded
Clin Cancer Res2014PMID 25303977PMC4367811stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerSkin Squamous Cell Carcinomacbioportal_study1.00
- cancerSkin Squamous Cell Carcinomacivic_curation1.00
- geneKMT2Ccivic_curation1.00
- variantKMT2C Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25303977
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KMT2C Mutation1 | ||||||||
| (prognostic) | Skin Squamous Cell Carcinoma | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID1696Evaluation of 39 aggressive cutaneous squamous cell carcinomas revealed that tumors with a KMT2C mutation were 5x more likely to invade the bone (53% versus 10%; p=0.008). Patients with KMT2C mutatio… (full text at CIViC) PMID 25303977 · Pickering et al., 2014 · Open in CIViC | civic |