Publication
Response and acquired resistance to everolimus in anaplastic thyroid cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (7)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 7
- cancerThyroid Gland Anaplastic Carcinomacivic_curation1.00
- cancerThyroid Gland Carcinomacivic_curation1.00
- drugEverolimuscivic_curation1.00
- geneMTORcivic_curation1.00
- geneTSC2civic_curation1.00
- variantMTOR F2108Lcivic_curation1.00
- variantTSC2 Q1178*civic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25295501
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| MTOR F2108L1 | ||||||||
| Everolimus | Thyroid Gland Anaplastic CarcinomaALIAS | Predictive | C | Supports Resistance | 5 | accepted | EID1110After an 18-month sustained response to everolimus (in a patient with metastatic anaplastic thyroid carcinoma whose pretreatment tumor harbored a TSC2 Q1178* inactivating mutation, see EID1108), the r… (full text at CIViC) PMID 25295501 · Wagle et al., 2014 · Open in CIViC | civic |
| TSC2 Q1178*1 | ||||||||
| Everolimus | Thyroid Gland Carcinoma | Predictive | C | Supports Sensitivity Response | 5 | accepted | EID1108In a phase II trial of everolimus in thyroid cancer (NCT00936858), seven patients with anaplastic thyroid carcinoma were treated, and only one patient achieved an objective response. This 57-year-old … (full text at CIViC) PMID 25295501 · Wagle et al., 2014 · Open in CIViC | civic |