Publication
The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.
Authors not recorded
Blood1989PMID 2499362stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerB Lymphoblastic Leukemia/Lymphoma with t(5;14)(q31.1;q32.3); IL3-IGHcivic_curation1.00
- geneIL3civic_curation1.00
- variantIL3 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 2499362
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| IL3 Fusion1 | ||||||||
| (diagnostic) | B Lymphoblastic Leukemia/Lymphoma with t(5;14)(q31.1;q32.3); IL3-IGHALIAS | Diagnostic | C | Supports Positive | 2 | accepted | EID12245In this 1989 study the authors analyzed the bone marrow aspirate from a B-ALL patient presenting with eosinophilia in the peripheral blood and found to have the t(5;14)(q31;q32) chromosomal translocat… (full text at CIViC) PMID 2499362 · Grimaldi et al., 1989 · Open in CIViC | civic |