Publication
Recurrent SMARCA4 mutations in small cell carcinoma of the ovary.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerLung Adenocarcinomacivic_curation1.00
- cancerOvarian Small Cell Carcinomacbioportal_study1.00
- geneSMARCA4civic_curation1.00
- variantSMARCA4 INACTIVATING MUTATIONcivic_curation1.00
- variantSMARCA4 Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24658004
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| SMARCA4 INACTIVATING MUTATION1 | ||||||||
| (prognostic) | Lung Adenocarcinoma | Prognostic | B | Supports Poor Outcome | 4 | accepted | EID513In patients with lung adenocarcinoma, those with loss-of-function mutations in SMARCA4 had worse overall survival than those with only missense or no mutations. PMID 24658004 · Jelinic et al., 2014 · Open in CIViC | civic |
| SMARCA4 Mutation1 | ||||||||
| (diagnostic) | Small-cell Carcinoma Of The Ovary Of Hypercalcemic TypeUNRESOLVED | Diagnostic | B | Supports Positive | 5 | accepted | EID512Nonsense mutations in SMARCA4 were associated with small cell carcinoma of the ovary, hypercalcemic type in 10/10 tumor samples, and were rarely found in other solid tumor types catalogued by TCGA. PMID 24658004 · Jelinic et al., 2014 · Open in CIViC | civic |