Publication
Characterization of rare transforming KRAS mutations in sporadic colorectal cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerColon Adenocarcinomacivic_curation1.00
- cancerMalignant Colorectal Neoplasmcivic_curation1.00
- geneKRAScivic_curation1.00
- variantKRAS A11_G12insGAcivic_curation1.00
- variantKRAS G10_A11insGcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24642870
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KRAS A11_G12insGA1 | ||||||||
| (oncogenic) | Colon Adenocarcinoma | Oncogenic | D | Supports Oncogenicity | 4 | accepted | EID9331FFPE tumor tissue from 1506 colorectal adenocarcinoma patients was analyzed at codons 12, 13, 61 and 146 by PCR. 672 KRAS mutations were found in 670 patients, and from these, two were inframe inserti… (full text at CIViC) PMID 24642870 · Tong et al., 2014 · Open in CIViC | civic |
| KRAS G10_A11insG1 | ||||||||
| (oncogenic) | Malignant Colorectal NeoplasmCURATED_BROADER | Oncogenic | D | Supports Oncogenicity | 4 | accepted | EID9330FFPE tumor tissue from 1506 colorectal cancer patients was analyzed at codons 12, 13, 61 and 146 by PCR. 672 KRAS mutations were found in 670 patients, and from these, two were inframe insertions loca… (full text at CIViC) PMID 24642870 · Tong et al., 2014 · Open in CIViC | civic |