Publication
Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (9)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 9
- cancerCutaneous Melanomacivic_curation1.00
- drugAkt Inhibitor MK2206civic_curation1.00
- drugMEK Inhibitor CI-1040civic_curation1.00
- drugPLX4720civic_curation1.00
- drugVemurafenibcivic_curation1.00
- geneGNAQcivic_curation1.00
- genePTENcivic_curation1.00
- variantGNAQ Q209Pcivic_curation1.00
- variantPTEN V317FScivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24504448
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| GNAQ Q209P2 | ||||||||
| PLX4720 | Cutaneous MelanomaALIAS | Predictive | D | Supports Resistance | 3 | accepted | EID1537Cells were derived from a 26-year old patient with vemurafenib resistant BRAF-mutated (V600E) cutaneous melanoma (designated 20 092 cells). Five of his metastases evaluated using whole genome sequenci… (full text at CIViC) PMID 24504448 · Turajlic et al., 2014 · Open in CIViC | civic |
| Vemurafenib | Cutaneous MelanomaALIAS | Predictive | C | Supports Resistance | 2 | accepted | EID1533A 26-year old patient presented with vemurafenib resistant BRAF-mutated (V600E) cutaneous melanoma. Five of his metastases were evaluated using whole genome sequencing. A GNAQ (Q209P) mutation was ide… (full text at CIViC) PMID 24504448 · Turajlic et al., 2014 · Open in CIViC | civic |
| PTEN V317FS1 | ||||||||
| Akt Inhibitor MK2206 + MEK Inhibitor CI-1040Combination | Cutaneous MelanomaALIAS | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1534A 26-year old patient presented with vemurafenib resistant BRAF V600E-mutated cutaneous melanoma. Five metastases were evaluated using whole genome sequencing and a 4-bp deletion in PTEN (frameshift m… (full text at CIViC) PMID 24504448 · Turajlic et al., 2014 · Open in CIViC | civic |