Publication
RSF1 and not cyclin D1 gene amplification may predict lack of benefit from adjuvant tamoxifen in high-risk pre-menopausal women in the MA.12 randomized clinical trial.
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- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerMalignant Breast Neoplasmcivic_curation1.00
- drugTamoxifencivic_curation1.00
- geneCCND1civic_curation1.00
- geneRSF1civic_curation1.00
- variantCCND1 Amplificationcivic_curation1.00
- variantRSF1 Amplificationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24367492
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CCND1 Amplification1 | ||||||||
| Tamoxifen | Malignant Breast Neoplasm | Predictive | B | Does Not Support Resistance | 3 | accepted | EID858In this retrospective analysis, CCND1 amplification was analyzed in 442 patients. No interaction with treatment was observed. PMID 24367492 · Keilty et al., 2013 · Open in CIViC | civic |
| RSF1 Amplification1 | ||||||||
| Tamoxifen | Malignant Breast Neoplasm | Predictive | B | Supports Resistance | 2 | accepted | EID857In retrospective study, 413 patients were assessed for RSF1 amplification. 28 patients with RSF1 amplification did not show a benefit from adjuvant tamoxifen compared to placebo (12 treated vs 16 plac… (full text at CIViC) PMID 24367492 · Keilty et al., 2013 · Open in CIViC | civic |