Publication
Activating ESR1 mutations in hormone-resistant metastatic breast cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (9)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 9
- cancerMalignant Breast Neoplasmcivic_curation1.00
- drugFulvestrantcivic_curation1.00
- drugTamoxifencivic_curation1.00
- geneESR1civic_curation1.00
- variantESR1 D538Gcivic_curation1.00
- variantESR1 L536Qcivic_curation1.00
- variantESR1 Y537Ccivic_curation1.00
- variantESR1 Y537Ncivic_curation1.00
- variantESR1 Y537Scivic_curation1.00
Curated evidence
Evidence citing this paper (5)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24185510
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ESR1 D538G1 | ||||||||
| Fulvestrant + TamoxifenSubstitutes | Malignant Breast Neoplasm | Predictive | D | Supports Sensitivity Response | 5 | accepted | EID291Using an estrogen response element (ERE)-luciferase reporter system co-transfected with one of five ESR1 mutants, the N538G ligand binding domain mutation was shown to result in constitutive activity … (full text at CIViC) PMID 24185510 · Robinson et al., 2013 · Open in CIViC | civic |
| ESR1 L536Q1 | ||||||||
| Fulvestrant + TamoxifenSubstitutes | Malignant Breast Neoplasm | Predictive | D | Supports Sensitivity Response | 5 | accepted | EID290Using an estrogen response element (ERE)-luciferase reporter system co-transfected with one of five ESR1 mutants, the L536Q ligand binding domain mutation was shown to result in constitutive activity … (full text at CIViC) PMID 24185510 · Robinson et al., 2013 · Open in CIViC | civic |
| ESR1 Y537C1 | ||||||||
| Fulvestrant + TamoxifenSubstitutes | Malignant Breast Neoplasm | Predictive | D | Supports Sensitivity Response | 5 | accepted | EID292Using an estrogen response element (ERE)-luciferase reporter system co-transfected with one of five ESR1 mutants, the Y537C ligand binding domain mutation was shown to result in constitutive activity … (full text at CIViC) PMID 24185510 · Robinson et al., 2013 · Open in CIViC | civic |
| ESR1 Y537N1 | ||||||||
| Fulvestrant + TamoxifenSubstitutes | Malignant Breast Neoplasm | Predictive | D | Supports Sensitivity Response | 5 | accepted | EID293Using an estrogen response element (ERE)-luciferase reporter system co-transfected with one of five ESR1 mutants, the Y537N ligand binding domain mutation was shown to result in constitutive activity … (full text at CIViC) PMID 24185510 · Robinson et al., 2013 · Open in CIViC | civic |
| ESR1 Y537S1 | ||||||||
| Fulvestrant + TamoxifenSubstitutes | Malignant Breast Neoplasm | Predictive | D | Supports Sensitivity Response | 5 | accepted | EID294Using an estrogen response element (ERE)-luciferase reporter system co-transfected with one of five ESR1 mutants, the Y537S ligand binding domain mutation was shown to result in constitutive activity … (full text at CIViC) PMID 24185510 · Robinson et al., 2013 · Open in CIViC | civic |