Publication
Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (7)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 7
- cancerCholangiocarcinomacivic_curation1.00
- drugInfigratinibcivic_curation1.00
- drugPD173074civic_curation1.00
- geneAHCYL1civic_curation1.00
- geneBICC1civic_curation1.00
- variantAHCYL1 Fusioncivic_curation1.00
- variantBICC1 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24122810
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| AHCYL1 Fusion2 | ||||||||
| (diagnostic) | Cholangiocarcinoma | Diagnostic | B | Supports Positive | 4 | accepted | EID1847Massively parallel whole transcriptome sequencing in eight specimens from cholangiocarcinoma patients identified two fusion kinase genes, FGFR2-AHCYL1 and FGFR2-BICC1. In RT-PCR screening, the FGFR2 f… (full text at CIViC) PMID 24122810 · Arai et al., 2014 · Open in CIViC | civic |
| Infigratinib + PD173074Substitutes | Cholangiocarcinoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1853Expression of the FGFR2-AHCYL1 fusion kinase in NIH3T3 cells demonstrated transforming ability that was effectively suppressed with the fibroblast growth factor receptor (FGFR) kinase inhibitors BGJ39… (full text at CIViC) PMID 24122810 · Arai et al., 2014 · Open in CIViC | civic |
| BICC1 Fusion2 | ||||||||
| (diagnostic) | Cholangiocarcinoma | Diagnostic | B | Supports Positive | 4 | accepted | EID1846Massively parallel whole transcriptome sequencing in eight specimens from cholangiocarcinoma patients identified two fusion kinase genes, FGFR2-AHCYL1 and FGFR2-BICC1. In RT-PCR screening, the FGFR2 f… (full text at CIViC) PMID 24122810 · Arai et al., 2014 · Open in CIViC | civic |
| Infigratinib + PD173074Substitutes | Cholangiocarcinoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1851Expression of the FGFR2-BICC1 fusion kinase in NIH3T3 cells demonstrated transforming ability that was effectively suppressed with the fibroblast growth factor receptor (FGFR) kinase inhibitors BGJ398… (full text at CIViC) PMID 24122810 · Arai et al., 2014 · Open in CIViC | civic |