Publication
High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerMalignant Pancreatic Neoplasmcivic_curation1.00
- drugNiacinamidecivic_curation1.00
- geneSIRT1civic_curation1.00
- variantSIRT1 Overexpressioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24088390
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| SIRT1 Overexpression2 | ||||||||
| Niacinamide | Malignant Pancreatic Neoplasm | Predictive | D | Supports Resistance | 1 | accepted | EID1294In-vitro study with MiaPaCa-2 and PANC-1 pancreatic cancer cell lines. Inhibition of Sirt1 by increasing concentrations of nicotinamide led to a decrease in viability. Gefitinib treatment with concent… (full text at CIViC) PMID 24088390 · Stenzinger et al., 2013 · Open in CIViC | civic |
| (prognostic) | Pancreatic Ductal CarcinomaUNRESOLVED | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID1293Nuclear Sirt1 expression was identified by IHC in 36 (27.9%) of 129 pancreatic ductal adenocarcinoma cases. SIRT1 expression was associated with poor survival in univariate (p = 0.002) and multivariat… (full text at CIViC) PMID 24088390 · Stenzinger et al., 2013 · Open in CIViC | civic |