Publication
The AKT inhibitor AZD5363 is selectively active in PI3KCA mutant gastric cancer, and sensitizes a patient-derived gastric cancer xenograft model with PTEN loss to Taxotere.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (7)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 7
- cancerMalignant Gastric Neoplasmcivic_curation1.00
- drugCapivasertibcivic_curation1.00
- drugDocetaxelcivic_curation1.00
- genePIK3CAcivic_curation1.00
- genePTENcivic_curation1.00
- variantPIK3CA Mutationcivic_curation1.00
- variantPTEN Losscivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24088382
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PIK3CA E542K + PTEN LossPIK3CAPTEN1 | ||||||||
| Capivasertib | Malignant Gastric Neoplasm | Predictive | D | Supports Sensitivity Response | 2 | submitted | EID11063In a panel of 20 gastric cancer cell lines, the line that showed greatest sensitivity to AZD5363 in MTS cell proliferation assay contained both PIK3CA E542K and PTEN Loss. PMID 24088382 · Li et al., 2013 · Open in CIViC | civic |
| PIK3CA Mutation1 | ||||||||
| Capivasertib | Malignant Gastric Neoplasm | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1501In a panel of 22 gastric cancer cell lines, 4 of 6 cell lines having the highest sensitivity to AZD5363 contained a PIK3CA mutation (E542K, E453K, E545K). A patient derived gastric cancer xenograft mo… (full text at CIViC) PMID 24088382 · Li et al., 2013 · Open in CIViC | civic |
| PTEN Loss2 | ||||||||
| Capivasertib + DocetaxelCombination | Malignant Gastric Neoplasm | Predictive | D | Supports Sensitivity Response | 1 | accepted | EID1500A patient derived mouse xenograft model was established with gastric cancer cells having PTEN loss. The xenograft was resistant to monotherapy with both the pan-Akt inhibitor AZD5363, and also to the … (full text at CIViC) PMID 24088382 · Li et al., 2013 · Open in CIViC | civic |
| Docetaxel | Malignant Gastric Neoplasm | Predictive | D | Supports Resistance | 2 | accepted | EID11064SGC020 was a gastric PDGCX mouse model established from a gastric cancer patient, with a PTEN exon 2-6 gene deletion resulting in undetectable PTEN protein expression. The chemotherapy Taxotere was gi… (full text at CIViC) PMID 24088382 · Li et al., 2013 · Open in CIViC | civic |