Publication
EZH2 mutations are frequent and represent an early event in follicular lymphoma.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (9)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 9
- cancerFollicular Lymphomacivic_curation1.00
- geneEZH2civic_curation1.00
- variantEZH2 A682Gcivic_curation1.00
- variantEZH2 A692Vcivic_curation1.00
- variantEZH2 Y646Ccivic_curation1.00
- variantEZH2 Y646Fcivic_curation1.00
- variantEZH2 Y646Hcivic_curation1.00
- variantEZH2 Y646Ncivic_curation1.00
- variantEZH2 Y646Scivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24052547
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| EZH2 A682G1 | ||||||||
| (oncogenic) | Follicular Lymphoma | Oncogenic | B | Supports Oncogenicity | 3 | accepted | EID12876In this 2013 study, the authors analyzed 366 follicular lymphoma (FL) patients with additional paired samples from 33 cases of transformed FL. Patients harbored EZH2 mutations predominantly at codons … (full text at CIViC) PMID 24052547 · Bödör et al., 2013 · Open in CIViC | civic |
| EZH2 A692V1 | ||||||||
| (oncogenic) | Follicular Lymphoma | Oncogenic | B | Supports Oncogenicity | 3 | submitted | EID12885In this study, 366 patients with follicular lymphoma were analyzed using next-generation sequencing and Sanger sequencing to evaluate EZH2 variants. EZH2 variants were identified in 101 patients (27.6… (full text at CIViC) PMID 24052547 · Bödör et al., 2013 · Open in CIViC | civic |
| EZH2 A682G + EZH2 A692V + EZH2 Y646C + EZH2 Y646F + EZH2 Y646H + EZH2 Y646N + EZH2 Y646S1 | ||||||||
| (oncogenic) | Follicular Lymphoma | Oncogenic | B | Supports Oncogenicity | 4 | accepted | EID11111In this large cohort study, 366 patients with follicular lymphoma (FL) were recruited to investigate the incidence and distribution of EZH2 mutations. NGS and Sanger detected EZH2 positive mutations i… (full text at CIViC) PMID 24052547 · Bödör et al., 2013 · Open in CIViC | civic |