Publication
PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system.
Authors not recorded
Clin Cancer Res2013PMID 23888070PMC3805128stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (7)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 7
- cancerMalignant Breast Neoplasmcivic_curation1.00
- drugAkt Inhibitor MK2206civic_curation1.00
- drugPictilisibcivic_curation1.00
- geneAKT1civic_curation1.00
- genePIK3CAcivic_curation1.00
- variantAKT1 E17Kcivic_curation1.00
- variantPIK3CA E545Kcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23888070
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| AKT1 E17K1 | ||||||||
| Akt Inhibitor MK2206 | Malignant Breast Neoplasm | Predictive | D | Does Not Support Sensitivity Response | 3 | accepted | EID231Breast cancer cell lines with the AKT1 E17K mutation did not show sensitivity to AKT inhibitor MK-2206, unlike cell lines with PIK3CA mutations. PMID 23888070 · Beaver et al., 2013 · Open in CIViC | civic |
| PIK3CA E545K1 | ||||||||
| Akt Inhibitor MK2206 + PictilisibSubstitutes | Malignant Breast Neoplasm | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID710PIK3CA E545K mutation increased sensitivity to AKT inhibitor MK-2206 and PI3K inhibitor GDC-0941 in a breast cancer cell line model. PMID 23888070 · Beaver et al., 2013 · Open in CIViC | civic |