Publication
Highly prevalent TERT promoter mutations in aggressive thyroid cancers.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerMalignant Thyroid Gland Neoplasmcivic_curation1.00
- geneTERTcivic_curation1.00
- variantTERT Promoter Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23766237
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TERT Promoter Mutation2 | ||||||||
| (diagnostic) | Malignant Thyroid Gland Neoplasm | Diagnostic | B | Supports Positive | 3 | accepted | EID657TERT promoter mutations are prevalent in aggressive sub-types of thyroid cancers. This work showed that TERT promoter mutations were significantly more prevalent in the tall cell papillary thyroid car… (full text at CIViC) PMID 23766237 · Liu et al., 2013 · Open in CIViC | civic |
| (prognostic) | Malignant Thyroid Gland Neoplasm | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID658TERT promoter mutation C228T is significantly associated with BRAF V600E mutation, a marker of more aggressive tumors, in papillary thyroid cancer (PTC). Conversely, the BRAF V600E mutation is signifi… (full text at CIViC) PMID 23766237 · Liu et al., 2013 · Open in CIViC | civic |