Publication
Cowden syndrome-related mutations in PTEN associate with enhanced proteasome activity.
Authors not recorded
Cancer Res2013PMID 23475934PMC3655114stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (2)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 2
- genePTENcivic_curation1.00
- variantPTEN C136Rcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23475934
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PTEN C136R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | accepted | EID9421In PHTS-derived lymphoblasts, PTEN protein expression, PTEN mRNA levels, and proteasome activity was measured in the PTEN C136R and control cells. In PTEN-C136R cells, PTEN protein expression was sign… (full text at CIViC) PMID 23475934 · He et al., 2013 · Open in CIViC | civic |