Publication
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerCutaneous Melanomacivic_curation1.00
- drugAZ628civic_curation1.00
- drugVemurafenibcivic_curation1.00
- drugVTX-11ecivic_curation1.00
- geneNF1civic_curation1.00
- variantNF1 Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23288408
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NF1 Mutation2 | ||||||||
| Vemurafenib | Cutaneous MelanomaALIAS | Predictive | C | Supports Resistance | 4 | accepted | EID1470NF1 was identified in an unbiased RNAi screen as mediator of resistance to BRAF inhibition in BRAF mutant melanoma. Knockdown of NF1 led to PLX4720 resistance in-vitro. MEK inhibition with AZD6244 (se… (full text at CIViC) PMID 23288408 · Whittaker et al., 2013 · Open in CIViC | civic |
| AZ628 + VTX-11eSubstitutes | Cutaneous MelanomaALIAS | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID1471NF1 was identified in an unbiased RNAi screen as mediator of resistance to BRAF inhibition in BRAF mutant melanoma. BRAF V600E/NF1 mutant cell lines were sensitive to ERK inhibition with VTX-11e, mode… (full text at CIViC) PMID 23288408 · Whittaker et al., 2013 · Open in CIViC | civic |
| NF1 R163X1 | ||||||||
| Vemurafenib | Melanoma | Predictive | C | Supports Resistance | — | submitted | EID4730In a retrospective study of four relapsed, malignant melanoma patients, NF1 R2450* mutation was associated with acquired resistance to vemurafenib monotherapy in one patient. PMID 23288408 · Whittaker et al., 2013 · Open in CIViC | civic |