Publication
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerDiffuse Large B-Cell Lymphomacivic_curation1.00
- geneEZH2civic_curation1.00
- variantEZH2 Y646Ncivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23236167
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| EZH2 Y646F2 | ||||||||
| (oncogenic) | Diffuse Large B-Cell LymphomaCURATED_BROADER | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID11012A selective EZH2 inhibitor (EI1) and siRNA were used to inhibit EZH2 Y641F mutation in DLBCL mutated cell line (WSU-DLCL2). Two independent siRNAs knocked down EZH2 mRNA by almost 80% and inhibited c… (full text at CIViC) PMID 23236167 · Qi et al., 2012 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 2 | submitted | EID11010DLBCL cell line carrying the EZH2 Y641F mutation (WSU-DLCL2 ) was used to study the effect of a selective EZH2 inhibitor (EI1) on these cells. Immunoblot assay showed an increase in baseline H3K27me3 … (full text at CIViC) PMID 23236167 · Qi et al., 2012 · Open in CIViC | civic |
| EZH2 Y646N2 | ||||||||
| (oncogenic) | Diffuse Large B-Cell LymphomaCURATED_BROADER | Oncogenic | D | Supports Oncogenicity | 4 | accepted | EID11013A selective EZH2 inhibitor (EI1) was used to target the EZH2 Y641N mutation in DLBCL cell lines. EI1 treatment significantly inhibited proliferation in EZH2-mutated cells compared to lymphoma cells wi… (full text at CIViC) PMID 23236167 · Qi et al., 2012 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | accepted | EID11011DLBCL cell lines carrying the EZH2 Y641N mutation (SU-DHL6 and Karpas422) were used to study the effect of EI1, a selective EZH2 inhibitor that functions by competing with the methyl group donor S-Ade… (full text at CIViC) PMID 23236167 · Qi et al., 2012 · Open in CIViC | civic |