Publication
Recurrent SETBP1 mutations in atypical chronic myeloid leukemia.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerAtypical Chronic Myeloid Leukemiacivic_curation1.00
- cancerChronic Myeloid Leukemia, BCR-ABL1 Positivecivic_curation1.00
- geneSETBP1civic_curation1.00
- variantSETBP1 Exon 4 Mutationcivic_curation1.00
- variantSETBP1 G870Scivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23222956
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| SETBP1 Exon 4 Mutation1 | ||||||||
| (prognostic) | Atypical Chronic Myeloid LeukemiaALIAS | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID839Atypical Chronic Myeloid Leukemia has the same symptoms as CML, but it lacks the BCR-ABL1 fusion. Targeted sequencing of 70 aCML patients identified SETBP1 mutations between codons 858 and 871 in 24.3… (full text at CIViC) PMID 23222956 · Piazza et al., 2013 · Open in CIViC | civic |
| SETBP1 G870S1 | ||||||||
| (oncogenic) | Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID840Atypical Chronic Myeloid Leukemia has the same symptoms as CML, but it lacks the BCR-ABL1 fusion. The researchers transfected 293T cells with SETBP1 G870S, a variant found to be associated with poor p… (full text at CIViC) PMID 23222956 · Piazza et al., 2013 · Open in CIViC | civic |