Publication
AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines.
Authors not recorded
PLoS One2012PMID 23056499PMC3462763stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerThyroid Gland Medullary Carcinomacivic_curation1.00
- drugJAK2 Inhibitor AZD1480civic_curation1.00
- geneRETcivic_curation1.00
- variantRET M918Tcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23056499
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| RET M918T1 | ||||||||
| JAK2 Inhibitor AZD1480 | Thyroid Gland Medullary CarcinomaALIAS | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID77The use of AZD1480 on RET-mutated/rearranged cell lines in vitro led to strong repression of tyroid cancer cell growth. PMID 23056499 · Couto et al., 2012 · Open in CIViC | civic |