Publication

Prognostic value of K-ras mutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer.

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J Gastroenterol2013PMID 22983505stubpubmedPublished

Abstract

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Linked entities

Linked entities (3)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 3

cancerMalignant Pancreatic Neoplasmcivic_curation1.00
geneKRAScivic_curation1.00
variantKRAS G12Rcivic_curation1.00

Curated evidence

Evidence citing this paper (2)

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
KRAS G12R2
(prognostic)	Malignant Pancreatic Neoplasm	Prognostic	B	Supports Poor Outcome	4	accepted	EID1298 In 242 patients with unresectable pancreatic cancer, the presence of KRAS G12R (N=17) or G12D (N=92) was associated with poorer prognosis (overall survival HR 1.6; 95% confidence interval 1.11-2.28). PMID 22983505 · Ogura et al., 2013 · Open in CIViC	civic
〃	Malignant Pancreatic Neoplasm	Prognostic	B	Supports Poor Outcome	4	rejected	EID1299 In 242 patients with unresectable pancreatic cancer, the presence of KRAS G12R (as well as G12D) was associated with poorer prognosis (95% confidence interval of HR between 1.11 and 2.28). PMID 22983505 · Ogura et al., 2013 · Open in CIViC	civic