Publication
Genome sequencing identifies a basis for everolimus sensitivity.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerBladder Carcinomacivic_curation1.00
- cancerInvasive Bladder Urothelial Carcinomacivic_curation1.00
- drugEverolimuscivic_curation1.00
- geneTSC1civic_curation1.00
- variantTSC1 Frameshift Truncationcivic_curation1.00
- variantTSC1 Loss-of-functioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22923433
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TSC1 Loss-of-function1 | ||||||||
| Everolimus | Bladder Carcinoma | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID155Tumors (n=14) expressing TSC1 mutations (5/14) show notably more sensitivity to everolimus than their wild-type counterparts (9/14). A dramatic response was observed in a patient with combination of L… (full text at CIViC) PMID 22923433 · Iyer et al., 2012 · Open in CIViC | civic |
| TSC1 Frameshift Truncation1 | ||||||||
| Everolimus | Invasive Bladder Urothelial CarcinomaALIAS | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID320A patient with metastatic bladder cancer that responded well to the mTOR inhibitor everolimus was shown to harbor a TSC1 frameshift truncation mutation (c.1907_1908del, p.Glu636fs) and a nonsense NF2 … (full text at CIViC) PMID 22923433 · Iyer et al., 2012 · Open in CIViC | civic |