Publication
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMelanomacivic_curation1.00
- drugVemurafenibcivic_curation1.00
- geneBRAFcivic_curation1.00
- variantBRAF V600Ecivic_curation1.00
- variantBRAF V600Kcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22356324
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BRAF V600E + BRAF V600K1 | ||||||||
| Vemurafenib | Melanoma | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID1410Phase 2 trial in 132 patients with previously treated metastatic melanoma with BRAF V600E (n=122) or V600K (n=10) mutation. Confirmed overall response rate was 53% (95% confidence interval [CI], 44 t… (full text at CIViC) PMID 22356324 · Sosman et al., 2012 · Open in CIViC | civic |
| BRAF V600K1 | ||||||||
| Vemurafenib | Melanoma | Predictive | B | Supports Sensitivity Response | 2 | submitted | EID4175In a phase 2 clinical trial (NCT00949702) of 344 BRAF V600 mutation, positive advanced melanoma patients, patients with BRAF V600K (n=10) mutation treated with vemurafenib monotherapy were associated … (full text at CIViC) PMID 22356324 · Sosman et al., 2012 · Open in CIViC | civic |