Publication
BRCA1 is an essential mediator of vinorelbine-induced apoptosis in mesothelioma.
Authors not recorded
J Pathol2012PMID 22190288stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerMalignant Mesotheliomacivic_curation1.00
- drugVinorelbinecivic_curation1.00
- geneBRCA1civic_curation1.00
- variantBRCA1 Expressioncivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22190288
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BRCA1 Expression1 | ||||||||
| Vinorelbine | Malignant Mesothelioma | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID933Expression of BRCA1 in 6 mesothelioma cell lines was associated with sensitivity to vinorelbine in functional studies. PMID 22190288 · Busacca et al., 2012 · Open in CIViC | civic |