Publication
Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerNeuroblastomacivic_curation1.00
- drugCrizotinibcivic_curation1.00
- geneALKcivic_curation1.00
- variantALK F1174Lcivic_curation1.00
- variantALK R1275Qcivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22072639
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ALK F1174L2 | ||||||||
| Crizotinib | Neuroblastoma | Predictive | B | Supports Resistance | — | rejected | EID2344Activating mutations in the (ALK) gene are targeted by the dual-specific tyrosine kinase inhibitor crizotinib. The amino acid substitution F1174L resulted in a reduced response to crizotinib compared … (full text at CIViC) PMID 22072639 · Bresler et al., 2011 · Open in CIViC | civic |
| 〃 | Neuroblastoma | Predictive | D | Supports Resistance | 3 | accepted | EID125Cells lines expressing ALK harboring the F1174L mutation are less sensitive to growth inhibition by crizotinib than cells expressing the R1275Q mutation. The authors conclude that this effect should b… (full text at CIViC) PMID 22072639 · Bresler et al., 2011 · Open in CIViC | civic |
| ALK R1275Q2 | ||||||||
| Crizotinib | Neuroblastoma | Predictive | B | Supports Sensitivity Response | — | rejected | EID2341Activating mutations in the (ALK) gene are targeted by the dual-specific tyrosine kinase inhibitor crizotinib. The amino acid substitution R1275Q resulted in an improved response to crizotinib. PMID 22072639 · Bresler et al., 2011 · Open in CIViC | civic |
| 〃 | Neuroblastoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID143Cells lines expressing ALK harboring the F1174L mutation are less sensitive to growth inhibition by crizotinib than cells expressing the R1275Q mutation. PMID 22072639 · Bresler et al., 2011 · Open in CIViC | civic |