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Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1.

Authors not recorded

Blood2011PMID 21719597PMC6710561stubpubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-CIVIC-20260908-000001
Published

Abstract

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Linked entities

Linked entities (6)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 6

Curated evidence

Evidence citing this paper (2)

civicProvenance
Source
CIViC — Clinical Interpretation of Variants in Cancer
Dataset
CIViC evidence items
Version
civic-2026-09-08
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Evidence
expert curation
License
CC0 1.0
PMID
21719597
Run
ING-CIVIC-20260908-000001
Open at source CuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.
TherapyCancerTypeLevelDirection · significanceRating (1–5)StatusEvidenceSource
NPM1 EXON 11 MUTATION1
NSC348884 + TretinoinCombinationAcute Myeloid LeukemiaCURATED_BROADERPredictiveDSupports Sensitivity Response3accepted
EID149

NSC348884 combined with ATRA treatment induces apoptosis in primary AML cells harboring mutant NPM1 but not in cells with wildtype NPM1 or both mutant NPM1 and FLT3-ITD.

PMID 21719597 · Balusu et al., 2011 · Open in CIViC

civic
NPM1 W288FS1
NSC348884Acute Myeloid LeukemiaCURATED_BROADERPredictiveDSupports Sensitivity Response3accepted
EID152

NSC348884 induced apoptosis in OPI-AML3 cells harboring an NPM1 mutation.

PMID 21719597 · Balusu et al., 2011 · Open in CIViC

civic