Publication
Both BRAF V600E mutation and older age (≥ 65 years) are associated with recurrent papillary thyroid cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerMalignant Thyroid Gland Neoplasmcivic_curation1.00
- cancerThyroid Gland Papillary Carcinomacivic_curation1.00
- geneBRAFcivic_curation1.00
- variantBRAF V600Ecivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21594703
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BRAF V600E3 | ||||||||
| (diagnostic) | Malignant Thyroid Gland Neoplasm | Diagnostic | B | Supports Positive | 3 | accepted | EID79BRAF V600E is shown to be associated with the tall-cell variant of papillary thyroid cancer. PMID 21594703 · Howell et al., 2011 · Open in CIViC | civic |
| (prognostic) | Thyroid Gland Papillary CarcinomaALIAS | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID105BRAF mutation correlated with poor prognosis in papillary thyroid cancer in both older (>65 yo) and younger (<65 yo) cohorts. PMID 21594703 · Howell et al., 2011 · Open in CIViC | civic |
| 〃 | Thyroid Gland Papillary CarcinomaALIAS | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID107V600E is correlated with disease recurrence in both age cohorts (>65 and <65 yo). PMID 21594703 · Howell et al., 2011 · Open in CIViC | civic |