Publication
The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations.
Authors not recorded
Clin Cancer Res2011PMID 21558396stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Breast Neoplasmcivic_curation1.00
- drugIzorlisibcivic_curation1.00
- genePIK3CAcivic_curation1.00
- variantPIK3CA E542Kcivic_curation1.00
- variantPIK3CA H1047Rcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21558396
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PIK3CA E542K1 | ||||||||
| Izorlisib | Malignant Breast Neoplasm | Predictive | D | Supports Sensitivity Response | 4 | accepted | EID310Breast cancer cell lines with E542K/E545K mutations showed increased sensitivity to CH5132799 than cells with wild-type PIK3CA gene. PMID 21558396 · Tanaka et al., 2011 · Open in CIViC | civic |
| PIK3CA H1047R1 | ||||||||
| Izorlisib | Malignant Breast Neoplasm | Predictive | D | Supports Sensitivity Response | 4 | accepted | EID314Breast cancer cell lines with H1047R mutation showed increased sensitivity to CH5132799 than cells with wild-type PIK3CA gene. PMID 21558396 · Tanaka et al., 2011 · Open in CIViC | civic |