Publication
Gain of function of mutant p53 by coaggregation with multiple tumor suppressors.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (2)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 2
- geneTP53civic_curation1.00
- variantTP53 P250Lcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21445056
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TP53 P250L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 5 | accepted | EID9285In a pre-clinical study, wild-type and P250L TP53 were transiently overexpressed in the human osteosarcoma SaOS-2 cell line, which lacks endogenous p53. Immunofluorescence revealed that the P250L muta… (full text at CIViC) PMID 21445056 · Xu et al., 2011 · Open in CIViC | civic |
| TP53 R110L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 4 | submitted | EID9133In preclinical experiments wild-type and R110L mutant TP53 were expressed in SaOS-2 cells that are devoid of endogenous TP53 expression. Immunofluorescence showed nuclear staining of wild-type p53 whe… (full text at CIViC) PMID 21445056 · Xu et al., 2011 · Open in CIViC | civic |