Publication
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerMyelodysplastic Syndromecivic_curation1.00
- geneDNMT3Acivic_curation1.00
- variantDNMT3A Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21415852
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| DNMT3A Mutation1 | ||||||||
| (prognostic) | Myelodysplastic SyndromeCURATED_BROADER | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID123812/150 patients with de novo myelodysplastic syndrome screened for DNMT3A mutations (bone marrow and paired normal skin) had heterozygous mutations with predicted translational consequences. 1 patient… (full text at CIViC) PMID 21415852 · Walter et al., 2011 · Open in CIViC | civic |
| DNMT3A P904L1 | ||||||||
| 5-Fluoro-2-Deoxycytidine + Azacitidine + Decitabine + GuadecitabineCombination | Myelodysplastic SyndromeCURATED_BROADER | Predictive | E | Supports Sensitivity Response | 3 | rejected | EID1134Previously only reported in haematopoietic and lymphoid malignancies, P904 is a likely activating event, whose function has not been well characterized. In the tertiary protein structure, the mutation… (full text at CIViC) PMID 21415852 · Walter et al., 2011 · Open in CIViC | civic |