Publication
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- geneEZH2civic_curation1.00
- variantEZH2 Y646Fcivic_curation1.00
- variantEZH2 Y646Hcivic_curation1.00
- variantEZH2 Y646Ncivic_curation1.00
- variantEZH2 Y646Scivic_curation1.00
Curated evidence
Evidence citing this paper (7)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21190999
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| EZH2 Y646F3 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | rejected | EID9516H3K27me3 level was higher in EZH2 (Y641F) bearing GCB-derived lymphoma cell lines and tumors than in wild-type cells. Expression of Y641F mutation in HEK293T cells with wild-type EZH2 led to an increa… (full text at CIViC) PMID 21190999 · Yap et al., 2011 · Open in CIViC | civic |
| 〃 | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | accepted | EID9517H3K27me3 (histone H3 Lys-27–specific trimethylation) level was higher in EZH2 (Y641F) bearing germinal center B-cell type DLBCL derived lymphoma cell lines and tumors than in wild-type cells. There wa… (full text at CIViC) PMID 21190999 · Yap et al., 2011 · Open in CIViC | civic |
| 〃 | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | accepted | EID9519A 3H methyl incorporation assay tested the function of EZH2 Y641F containing PRC2 complexes in vitro. It showed that Y641F/N PRC2 complexes had significantly decreased enzyme activity on unmethylated … (full text at CIViC) PMID 21190999 · Yap et al., 2011 · Open in CIViC | civic |
| EZH2 Y646H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | accepted | EID9521Whole-cell lysates from frozen GCB-derived lymphoma sections with EZH2 Y641H showed a higher level of H3K27me3 (histone H3 Lys-27–specific trimethylation) compared with those from tumor with wild-type… (full text at CIViC) PMID 21190999 · Yap et al., 2011 · Open in CIViC | civic |
| EZH2 Y646N2 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | accepted | EID9518H3K27me3 (histone H3 Lys-27–specific trimethylation) level was higher in EZH2 (Y641N) bearing germinal center B-cell type DLBCL derived lymphoma cell lines and tumors than in wild-type cells. There wa… (full text at CIViC) PMID 21190999 · Yap et al., 2011 · Open in CIViC | civic |
| 〃 | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | accepted | EID9520A 3H methyl incorporation assay tested the function of EZH2 Y641N containing PRC2 complexes in vitro. It showed that Y641F/N PRC2 complexes had significantly decreased enzyme activity on unmethylated … (full text at CIViC) PMID 21190999 · Yap et al., 2011 · Open in CIViC | civic |
| EZH2 Y646S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | accepted | EID9522Whole-cell lysates from frozen GCB-derived lymphoma sections with EZH2 Y641H showed a higher level of H3K27me3 (histone H3 Lys-27–specific trimethylation) compared with those from tumor with wild-type… (full text at CIViC) PMID 21190999 · Yap et al., 2011 · Open in CIViC | civic |