Publication
Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerMalignant Breast Neoplasmcivic_curation1.00
- cancerRenal Cell Carcinomacivic_curation1.00
- geneKLLNcivic_curation1.00
- variantKLLN PROMOTER METHYLATIONcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21177507
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KLLN PROMOTER METHYLATION2 | ||||||||
| (predisposing) | Malignant Breast Neoplasm | Predisposing | B | Supports Predisposition | 3 | accepted | EID1761123 patients with Cowden or Cowden-like syndrome (from the IRB8458-PTEN series) and 50 unaffected individuals without PTEN variants were analyzed for germline methylation and expression of PTEN and KI… (full text at CIViC) PMID 21177507 · Bennett et al., 2010 · Open in CIViC | civic |
| 〃 | Renal Cell CarcinomaCURATED_BROADER | Predisposing | B | Supports Predisposition | 3 | accepted | EID1762123 patients with Cowden or Cowden-like syndrome (from the IRB8458-PTEN series) and 50 unaffected individuals without PTEN variants were analyzed for germline methylation and expression of PTEN and KI… (full text at CIViC) PMID 21177507 · Bennett et al., 2010 · Open in CIViC | civic |