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IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas.

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Neurology2010PMID 20975057stubpubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-CIVIC-20260908-000001
Published

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Linked entities

Linked entities (3)

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Validated 3

Curated evidence

Evidence citing this paper (5)

civicProvenance
Source
CIViC — Clinical Interpretation of Variants in Cancer
Dataset
CIViC evidence items
Version
civic-2026-09-08
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Evidence
expert curation
License
CC0 1.0
PMID
20975057
Run
ING-CIVIC-20260908-000001
Open at source CuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.
TherapyCancerTypeLevelDirection · significanceRating (1–5)StatusEvidenceSource
IDH1 R132C1
TemozolomideBrain GliomaUNRESOLVEDPredictiveBSupports Sensitivity Response2accepted
EID2327

In a study of 189 low-grade gliomas, IDH (IDH1 or IDH2) mutations were found in 132 patients (70%). IDH mutations were associated with improved rate of response to temozolomide as compared to patients… (full text at CIViC)

PMID 20975057 · Houillier et al., 2010 · Open in CIViC

civic
IDH1 R132G1
TemozolomideBrain GliomaUNRESOLVEDPredictiveBSupports Sensitivity Response—submitted
EID2334

In a study of 189 low-grade gliomas, IDH (IDH1 or IDH2) mutations were found in 132 patients (70%). IDH mutations were associated with improved rate of response to temozolomide compared to wildtype ID… (full text at CIViC)

PMID 20975057 · Houillier et al., 2010 · Open in CIViC

civic
IDH1 R132H1
TemozolomideBrain GliomaUNRESOLVEDPredictiveBSupports Sensitivity Response—submitted
EID2323

In a study of 189 low-grade gliomas, IDH (IDH1 or IDH2) mutations were found in 132 patients (70%). IDH mutations were associated with improved rate of response to temozolomide compared to wildtype ID… (full text at CIViC)

PMID 20975057 · Houillier et al., 2010 · Open in CIViC

civic
IDH1 R132L1
TemozolomideBrain GliomaUNRESOLVEDPredictiveBSupports Sensitivity Response—submitted
EID2018

In a study of 189 low-grade gliomas, IDH (IDH1 or IDH2) mutations were found in 132 patients (70%). IDH mutations were associated with improved rate of response to temozolomide compared to wildtype ID… (full text at CIViC)

PMID 20975057 · Houillier et al., 2010 · Open in CIViC

civic
IDH1 R132S1
TemozolomideBrain GliomaUNRESOLVEDPredictiveBSupports Sensitivity Response—submitted
EID2337

In a study of 189 low-grade gliomas, IDH (IDH1 or IDH2) mutations were found in 132 patients (70%). IDH mutations were associated with improved rate of response to temozolomide compared to wildtype ID… (full text at CIViC)

PMID 20975057 · Houillier et al., 2010 · Open in CIViC

civic