Publication
RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerMelanomacivic_curation1.00
- drugVemurafenibcivic_curation1.00
- geneBRAFcivic_curation1.00
- variantBRAF V600Dcivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 20551065
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BRAF V600D1 | ||||||||
| Vemurafenib | Melanoma | Predictive | D | Supports Sensitivity Response | 4 | accepted | EID4489In an in vitro study, the WM2664 and WM239A cell lines expressing BRAF V600D were associated with increased sensitivity to vemurafenib treatment, as compared to cell lines expressing BRAF wild-type. S… (full text at CIViC) PMID 20551065 · Yang et al., 2010 · Open in CIViC | civic |
| BRAF V600E1 | ||||||||
| Vemurafenib | Melanoma | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID3753In an in vitro study, several cell lines (including MALME-3M, Colo829, Colo38, A375 and SK-MEK28) expressing BRAF V600E were associated with increased sensitivity to vemurafenib (RG7204) treatment, as… (full text at CIViC) PMID 20551065 · Yang et al., 2010 · Open in CIViC | civic |
| BRAF V600R1 | ||||||||
| Vemurafenib | Melanoma | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID4171In an in vitro study, the WM1341D cell line expressing BRAF V600R was associated with increased sensitivity to vemurafenib treatment, as compared to cell lines expressing BRAF wild-type. Sensitivity w… (full text at CIViC) PMID 20551065 · Yang et al., 2010 · Open in CIViC | civic |