Publication

Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner.

Authors not recorded

Oncogene2009PMID 19749790PMC2789045stubpubmedPublished

Abstract

Abstract (excerpt)

Only the opening of the abstract is shown; abstract text may carry publisher copyright.

Data not yet available

No abstract stored. Read on PubMed

Linked entities

Linked entities (5)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 5

cancerMalignant Bladder Neoplasmcivic_curation1.00
cancerTransitional Cell Carcinomacivic_curation1.00
geneFGFR3civic_curation1.00
variantFGFR3 S249Ccivic_curation1.00
variantFGFR3 Y373Ccivic_curation1.00

Curated evidence

Evidence citing this paper (2)

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FGFR3 Y373C1
(oncogenic)	Malignant Bladder NeoplasmALIAS	Oncogenic	D	Supports Oncogenicity	3	accepted	EID8880 Using site-directed mutagenesis, the authors investigated the phenotypic and signaling consequences of three FGFR3 mutations, S249C, Y373C (in the paper described as Y375C), and K652E, in immortalized… (full text at CIViC) PMID 19749790 · di Martino et al., 2009 · Open in CIViC	civic
FGFR3 S249C1
(oncogenic)	Transitional Cell Carcinoma	Oncogenic	D	Supports Oncogenicity	3	accepted	EID8855 Compared to controls (empty vector, FGFR3 wildtype, and S249C-Kinase dead cell lines), stable expression of S249C in NIH-3T3 cells resulted in a transformed spindle-like morphology, a 3-fold prolifera… (full text at CIViC) PMID 19749790 · di Martino et al., 2009 · Open in CIViC	civic