Publication
Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (8)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 8
- cancerMalignant Thyroid Gland Neoplasmcivic_curation1.00
- drugPerifosinecivic_curation1.00
- drugTemsirolimuscivic_curation1.00
- genePIK3CAcivic_curation1.00
- genePTENcivic_curation1.00
- variantPIK3CA E542Kcivic_curation1.00
- variantPIK3CA H1047Rcivic_curation1.00
- variantPTEN R130*civic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 19706758
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PIK3CA E542K1 | ||||||||
| Perifosine + TemsirolimusSubstitutes | Malignant Thyroid Gland Neoplasm | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1626Preclinical study in thyroid cancer cell lines. 6 cell lines with alterations of the PI3K/Akt pathway were more sensitive to Akt inhibitor perifosine or MTOR inhibitor temsirolimus than 5 cell lines w… (full text at CIViC) PMID 19706758 · Liu et al., 2009 · Open in CIViC | civic |
| PIK3CA H1047R1 | ||||||||
| Perifosine + TemsirolimusSubstitutes | Malignant Thyroid Gland Neoplasm | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1625Preclinical study in thyroid cancer cell lines. 6 cell lines with alterations of the PI3K/Akt pathway were more sensitive to Akt inhibitor perifosine or MTOR inhibitor temsirolimus than 5 cell lines w… (full text at CIViC) PMID 19706758 · Liu et al., 2009 · Open in CIViC | civic |
| PTEN R130*1 | ||||||||
| Perifosine + TemsirolimusSubstitutes | Malignant Thyroid Gland Neoplasm | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID1627Preclinical study in thyroid cancer cell lines. 6 cell lines with alterations of the PI3K/Akt pathway were more sensitive to Akt inhibitor perifosine or MTOR inhibitor temsirolimus than 5 cell lines w… (full text at CIViC) PMID 19706758 · Liu et al., 2009 · Open in CIViC | civic |