Publication
Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates.
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- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities (7)
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Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 19671763
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BRAF V600E1 | ||||||||
| Dasatinib | Melanoma | Predictive | D | Does Not Support Sensitivity Response | 2 | submitted | EID3759In an in vitro study, a melanoma cell line, A375 (Amelanotic melanoma), expressing the BRAF V600E mutation was associated with resistance to dasatinib treatment, comparable to melanoma MEWO cells expr… (full text at CIViC) PMID 19671763 · Woodman et al., 2009 · Open in CIViC | civic |
| KIT L576P2 | ||||||||
| Dasatinib | Melanoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID42The melanoma cell line WM3211, which harbors the L576P mutation, is sensitive to dasatinib. Molecular modeling indicated the L576P mutation alters the conformation of KIT but did not alter the binding… (full text at CIViC) PMID 19671763 · Woodman et al., 2009 · Open in CIViC | civic |
| Imatinib + Nilotinib + SorafenibSubstitutes | Melanoma | Predictive | D | Supports Resistance | 3 | accepted | EID34The melanoma cell line WM3211 (derived from an acral lentiginous melanoma), which harbors the L576P mutation, is not sensitive to imatinib, nilotinib, and sorafenib. Molecular modeling indicated the L… (full text at CIViC) PMID 19671763 · Woodman et al., 2009 · Open in CIViC | civic |