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HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.

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Proc Natl Acad Sci U S A2009PMID 19122144PMC2626727stubpubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-CIVIC-20260908-000001
Published

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Linked entities

Linked entities (6)

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Validated 6

Curated evidence

Evidence citing this paper (3)

civicProvenance
Source
CIViC — Clinical Interpretation of Variants in Cancer
Dataset
CIViC evidence items
Version
civic-2026-09-08
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Evidence
expert curation
License
CC0 1.0
PMID
19122144
Run
ING-CIVIC-20260908-000001
Open at source CuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.
TherapyCancerTypeLevelDirection · significanceRating (1–5)StatusEvidenceSource
ERBB2 Y772_A775DUP3
AfatinibLung Adenosquamous CarcinomaALIASPredictiveDSupports Sensitivity Response4accepted
EID1047

Human HER2 with YVMA insertion was put under a clara cell specific, rtTA promoter system inducible via doxycycline. Induction of mutant HER2 in these mice drove rapid development of adenosquamous lung… (full text at CIViC)

PMID 19122144 · Perera et al., 2009 · Open in CIViC

civic
Afatinib + SirolimusCombinationLung CarcinomaPredictiveDSupports Sensitivity Response4rejected
EID1046

In mice, human HER2 with YVMA insertion was placed under a doxycycline-inducible, clara cell specific promoter. Induction of mutant HER2 in these mice drove rapid development of adenosquamous lung tum… (full text at CIViC)

PMID 19122144 · Perera et al., 2009 · Open in CIViC

civic
〃Lung Non-Small Cell CarcinomaCURATED_BROADERPredictiveDSupports Sensitivity Response3accepted
EID960

In preclinical studies of transgenic mice and xenografts, continuous expression of mutant ERBB2 (M774insAYVM or the equivalent A775insYVMA) was found to be essential for tumor maintenance. Furthermore… (full text at CIViC)

PMID 19122144 · Perera et al., 2009 · Open in CIViC

civic