Publication
Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer.
Authors not recorded
Cancer Res2009PMID 19117982PMC2614301stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerMalignant Prostate Neoplasmcivic_curation1.00
- geneARcivic_curation1.00
- variantAR AR-V7civic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 19117982
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| AR AR-V71 | ||||||||
| (oncogenic) | Malignant Prostate Neoplasm | Oncogenic | D | Supports Oncogenicity | 4 | accepted | EID12259Seven novel AR isoforms were identified through the examination of cryptic exon splicing at exon 3 of the AR gene. All seven isoforms encode truncated AR proteins, lacking the ligand binding domain. T… (full text at CIViC) PMID 19117982 · Hu et al., 2009 · Open in CIViC | civic |