Publication
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Data not yet available
Linked entities
Linked entities (7)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 7
- cancerLung Adenocarcinomacivic_curation1.00
- drugDactolisibcivic_curation1.00
- drugSelumetinibcivic_curation1.00
- geneKRAScivic_curation1.00
- genePIK3CAcivic_curation1.00
- variantKRAS G12Dcivic_curation1.00
- variantPIK3CA H1047Rcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 19029981
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KRAS G12D1 | ||||||||
| Dactolisib + SelumetinibCombination | Lung Adenocarcinoma | Predictive | D | Supports Sensitivity Response | 4 | accepted | EID305The use of NVP-BEZ235 in conjunction with ARRY-142886, but not as monotherapy, in a lung cancer mouse model with an inducible KRAS G12D mutation (lox-stop-lox KRAS G12D floxed via inhaled adenoviral C… (full text at CIViC) PMID 19029981 · Engelman et al., 2008 · Open in CIViC | civic |
| PIK3CA H1047R1 | ||||||||
| Dactolisib | Lung Adenocarcinoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1447Doxycycline dependent expression of the PIK3CA H1047R mutation in mouse type II alveolar epithelial cells drove lung cancer in a reversible fashion, indicating the driver properties of this p110alpha … (full text at CIViC) PMID 19029981 · Engelman et al., 2008 · Open in CIViC | civic |