Publication
CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerCutaneous Melanomacivic_curation1.00
- drugSorafenibcivic_curation1.00
- drugU0126civic_curation1.00
- geneBRAFcivic_curation1.00
- variantBRAF D594Gcivic_curation1.00
- variantBRAF G469Ecivic_curation1.00
Curated evidence
Evidence citing this paper (5)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 18794803
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BRAF D594G2 | ||||||||
| Sorafenib | Cutaneous MelanomaALIAS | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID6001In this preclinical study, melanoma cell lines harboring the kinase-dead G469E- and D594G mutations were identified. These cell lines were resitant to MEK-Inhibition but underwent apoptosis after shRN… (full text at CIViC) PMID 18794803 · Smalley et al., 2009 · Open in CIViC | civic |
| U0126 | Cutaneous MelanomaALIAS | Predictive | D | Supports Resistance | 3 | accepted | EID6002In this preclinical study, melanoma cell lines harboring the kinase-dead G469E- and D594G mutations were identified. These cell lines were resitant to MEK-Inhibition but underwent apoptosis after shRN… (full text at CIViC) PMID 18794803 · Smalley et al., 2009 · Open in CIViC | civic |
| BRAF G469E3 | ||||||||
| Sorafenib | Cutaneous MelanomaALIAS | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID6003In this preclinical study, melanoma cell lines harboring the kinase-dead G469E- and D594G mutations were identified. These cell lines were resitant to MEK-Inhibition but underwent apoptosis after shRN… (full text at CIViC) PMID 18794803 · Smalley et al., 2009 · Open in CIViC | civic |
| U0126 | Cutaneous MelanomaALIAS | Predictive | D | Supports Resistance | 3 | accepted | EID6004In this preclinical study, melanoma cell lines harboring the kinase-dead G469E- and D594G mutations were identified. These cell lines were resitant to MEK-Inhibition (U0126) but underwent apoptosis af… (full text at CIViC) PMID 18794803 · Smalley et al., 2009 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 5 | submitted | EID12984BRAF p.Gly469Glu (NM_004333.6:c.1406G>A) causes increased ratio of pERK/ERK, increased signaling through RAF1 (CRAF), it has low kinase activity. Class 3 BRAF variant. PMID 18794803 · Smalley et al., 2009 · Open in CIViC | civic |