Publication
Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer.
Authors not recorded
Cancer Res2008PMID 18593940stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Breast Neoplasmcivic_curation1.00
- drugMonomethyl Auristatin Ecivic_curation1.00
- drugPaclitaxelcivic_curation1.00
- geneABCC3civic_curation1.00
- variantABCC3 Amplificationcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 18593940
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ABCC3 Amplification1 | ||||||||
| Monomethyl Auristatin E + PaclitaxelSubstitutes | Malignant Breast Neoplasm | Predictive | D | Supports Resistance | 3 | accepted | EID95144 cell lines and 145 patient samples were utilized in various aspects of this study. 31 breast cancer cell lines for in vitro sensitivity to paclitaxel and Monomethyl Auristatin E (MMAE). Genome wide… (full text at CIViC) PMID 18593940 · O'Brien et al., 2008 · Open in CIViC | civic |